The first series follows life at a Manchester STI clinic.
At the Manchester Centre for Sexual Health, the staff treat 22-year-old Kervin, who has some issues to address after a one night stand leaves him with more than just a smile on his face. 17-year-old Courtney shocks her mum with lurid confessions of unprotected encounters in the park, while ladies man Joe discovers if putting it about has landed him in it.
20-year-old gay porn star Lloyd has a double dose of bad news from the clinic, 31-year-old Heidi is terrified that a bout of chlamydia as a teenager has left her infertile, and housemates Martin and Marissa can't agree who should carry the can for an outbreak of scabies.
John comes into the clinic hoping he won't be diagnosed with chlamydia for an astonishing fourth time, clinic staff provide sexual health care for the inmates of maximum security jail HMP Manchester and, after a drunken one night stand, 26-year-old student Ben tries to persuade his girlfriend to lift a sex ban by proving he's still STI-free.
Twenty-year-old Gary finds out the hard way that it's not just STIs condoms are designed to prevent. Pre-op transsexual Jasmine hopes her high-risk sexploits don't jeopardise her life-changing operation.